Mitochondria’s failure to supply energy to brain cells may be source of Alzheimer’s

Mitochondria’s failure to supply energy to brain cells may be source of Alzheimer’s

Power outage in the brain that prevents mitochondria from acting as energy centers for cells may be the source of the pitiless progressive disease of Alzheimer’s, a new research suggested.

A team of researchers led by Diego Mastroeni and Paul Coleman of the ASU-Banner Neurodegenerative Disease Research Center (NDRC) examined the role of mitochondria in the development of Alzheimer’s disease.

They found that gene mutations affecting functions of mitochondria might be critical in the development Alzheimer’s.

Sharing findings of the new study, Mastroeni said, “Findings from our laboratory have uncovered early expression changes in nuclear encoded, but not mitochondrial encoded mRNAs occurring in one's early thirties; giving us a glimpse into what we suspect are some of the earliest cellular changes in the progression of Alzheimer's disease.”

The researchers reached the conclusion after they found that a specific class of genes associated with mitochondrial cell respiration displayed decreased expression levels in patients suffering from Alzheimer's disease, as compared with normal people.

Alzheimer’s disease is characterized by decline in cognitive abilities, like mental decline, forgetfulness, confusion, delusion and disorientation. Behavioral conditions includes aggression, agitation, irritability and meaningless repetition of own words.
According to the Centers for Disease Control & Prevention (CDC), nearly 5 million Americans are currently in the grip of Alzheimer's disease. The number is projected to jump to more than 14 million by 2050.


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